What Is Methylcobalamin?

by Dr. Edward Group DC, NP, DACBN, DCBCN, DABFM Published on , Last Updated on


Methylcobalamin circulates through the bloodstream and is one of two naturally-occurring coenzyme forms of vitamin B12 that the body utilizes. Adenosylcobalamin is the other form sometimes used in the dietary supplement industry. The body needs B12 to convert homocysteine to methionine, protect DNA and RNA, support energy, protect nerve and brain cells, stimulate serotonin production, contribute to red blood cell formation, support immune function, and maintain a positive mood.

What’s So Great about Methylcobalamin?

Hydroxocobalamin is the main B12 form found in meat, fish, and dairy products. Cyanocobalamin is a common but synthetic B12 that is often added to foods, and the body must use precious energy to convert this form into methylcobalamin. This B12 form has a higher stability and bioavailability and doesn’t require conversion. These next 4 facts will explain the benefits of methylcobalamin.

1. Increases Available Physical Energy

Every chemical reaction in the body expends energy. When the body needs to convert a vitamin into a form the body can use, this reaction also requires energy. For example, supplementing with the cyanocobalamin form of B12 requires the body to expend energy that removes the cyanide molecule and replaces it with a methyl group. Taking methylcobalamin as a B12 supplement eliminates the need for this extra chemical reaction.

2. Encourages Detox

Methyl groups activate hundreds of chemical reactions throughout the body. One such process includes triggering detox reactions. This includes the removal of heavy metals, environmental toxins, and waste products.

3. Supports Brain and Nerve Health

Methylcobalamin is the only form of B12 that can cross the blood-brain barrier without assistance or conversion. Its methyl group stimulates serotonin creation, a neurotransmitter responsible for mood support. It also works directly on brain cells to protect against damage from excitotoxins. [1] Researchers have found large doses of methylcobalamin may offer therapeutic value for those suffering from ALS and multiple sclerosis. [2] [3] This is the only form of B12 that acts on the nervous system.

4. Neutralizes Homocysteine

High homocysteine levels is undesirable and known to be an indicator of heart disease and stroke risk. Free homocysteine in the blood causes sclerosis of the arteries, putting strain on the vascular system and the heart. One of the primary reactions of methylcobalamin is to convert homocysteine to methionine, reducing the potential for damage. Outcomes from this reaction include the formation of cysteine, a precursor to the super-antioxidant glutathione. Methionine also contributes to the formation of adenosylcobalamin, the other form of B12 used by the body in mitochondrial energy creation, the foundation for all human energy.

Supplementing with Methylcobalamin

Methylcobalamin supplementation has exploded in popularity. It’s the most functional B12 supplement because it’s already in bioavailable form, the body does not need to convert it. This offers a huge advantage over other types of vitamin B12. Sublingual supplementation of methylcobalamin is one of the most common ways it’s taken because of the quick absorption. When you’re deciding on a B12 supplement, find one that combines both methylcobalamin and adenosylcobalamin. I developed a formula called VeganSafe™ B-12, which not only offers both of these forms of B12, but is also vegan friendly and produced in the USA. It truly is the best quality B12 supplement available and we’ve gotten incredible feedback from our customers who’ve tried it.

Have you supplemented with methylcobalamin? How did it go? Share your thoughts and comments below.

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Everything You Need to Know About Vitamin B-12

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References (3)
  1. Kikuchi M, Kashii S, Honda Y, et al. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci. 1997 Apr;38(5): 848-54.
  2. Izumi Y1, Kaji R. Vitamin B12 metabolism and massive-dose methyl vitamin B12 therapy in Japanese patients with multiple sclerosis. Intern Med. 1994 Feb;33(2):82-6.

†Results may vary. Information and statements made are for education purposes and are not intended to replace the advice of your doctor. Global Healing Center does not dispense medical advice, prescribe, or diagnose illness. The views and nutritional advice expressed by Global Healing Center are not intended to be a substitute for conventional medical service. If you have a severe medical condition or health concern, see your physician.

  • Diannah Neptune

    I am a 69 yr old woman, what is the best dosage for methylcobalamin / day in chewable form?

  • Chewable… couldn’t tell you. I like Vegansafe B12, one dropper will give you 2500mcg of methylcobalamin and adenosylcobalamin, which is the best B12 combination.

  • Covalent Bond

    Hey … I am 23 years old female but I have alot of muscle sprain …. even after small workout I have to suffer muscle pain … and my hb is 10 … once a doctor recommend me methycobalamine injections but I didn’t took it serious
    .. what should I do now

  • If you suspect it’s because you’re not getting enough B12, you can always add a supplement to your day. Vegansafe B12 is what I use. It’s a combo of methyl and adeno cobalamins, which is ideal. Check out the reviews.

  • ryaneh

    Hello. Where do the Methylcobalamin and Adenosylcobalamin come from? What are the sources? Thanks!

  • sabelmouse

    any contraindications?

  • Theone

    eat more bananas

  • Barbara Koon

    I am a 70 year old woman and had just started taking the regular B12 supplements with cyanocobalamin. I started having more energy and was happy. Then I was reading something online and decided to try Methyl-cobalamin B12 lozenges (5mg). The energy I was feeling disappeared. Why is that? Should I take a higher dose?

  • GHC Support

    To determine why you have experienced the loss of energy it may be ideal to consider speaking with a reputable practitioner in your area to assist you in determining your personal needs and to help you review the supplement you have been using. Additionally you may consider VeganSafe B-12, which contains adenosylcobalamin and methylcobalamin, a combination that’s better absorbed and used more efficiently in your liver, brain, and nervous system.

  • Li Ha

    i would like to know as well researched everywhere to find out what methylcobalamin is made from and cannot find.

  • GHC Support

    Thank you for contacting GHC. The co-enzymes in
    VeganSafe B12 are derived from Brewer’s yeast through a special
    fermentation process.

  • chefjenny

    Hi, I’m 69 and started taking this about 2 weeks ago. I feel so much more energy I can’t believe it. I will recommend to anyone . Great product. Thanks

  • Christine Wess

    Is this safe for kids and what age kids and what doasge?


    Friday March 3, 2017
    I’m 72 and feel exhausted all the time. I have had both knees replaced and my left shoulder and have rods stabilizing my spine. So, I can’t exercise anymore. I barely move much unless I have some outside project to do. I mostly lay back on pillows in bed and read articles on the computer all day and night when I’m not sleeping.
    I eat a good diet of meat and vegetables and not too many sweets or carbs and take a multiple vitamin, coq10, vitamin D drops and iodine drops as I am hypothyroid since age 40.
    I used to take a mixture of brewer’s yeast and wheat germ each day. I wonder if I could get enough of the B vitamins from that?
    What will your drops do for me?

  • t isall

    would it be safe to take 2 droppers of the b12 combo

  • GHC Support

    Hi, thank you for contacting us. Although it may be
    best to stay within our suggested guidelines, you may take additional VeganSafe B-12 at your discretion, as this has worked well for other customers in the past. However, it’s important to note that consistent dosing is key with our supplements, and if you decide to take more, we recommend working with a trusted doctor or naturopathic physician.

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