The Health Benefits of Serrapeptase

by Dr. Edward Group DC, NP, DACBN, DCBCN, DABFM
Published on , Last Updated on

Discovered in the early 1970’s, this proteolytic enzyme was isolated from the Serratia species of bacteria located in the intestines of silkworms. Serrapeptase, also called serratiopeptidase, is a superior enzyme that provides strong, healthful properties. Today serrapeptase is used all over Europe and Asia in clinical settings. It can break down non-living tissue in the body.

Serrapeptase is one of the world’s most exciting enzymes studied regarding its wide variety of clinical applications. Currently, especially in Europe and Asia, it is clinically used for many health conditions. One of the most well-known proponents for this enzyme was the German physician, Dr. Hans Nieper. He had great success supplementing with serrapeptase to promote normal heart and circulatory system health.

How Does Serrapeptase Work?

Serrapeptase is an immunologically active enzyme. It can bind itself to the alpha 2 macroglobulin in our plasma where it is shielded from the immune system while retaining its enzymatic activity, and in this way, it is transferred to the sites where the body needs it. It is this same type of powerful yet specific action that allows silkworms to eat its own protective cocoon, digest it without any side effects and fly away. Amazingly, serrapeptase has the distinct ability to digest only non-living tissue allowing the old toxic layers that clog the digestive system and the lining of our arteries to dissolve. This is one reason why it’s so good at keeping arterial deposits from building up after heart surgery.

Health Benefits of Serrapeptase

1. Atherosclerosis

Dr. Nieper found that serrapeptase promoted normal blood clotting and reduced the appearance of varicose veins. Other studies found that serrapeptase effectively removes atherosclerotic plaque without hurting any of the healthy cells along the arterial wall.

2. Soothes Redness

Multiple studies confirm serrapeptase soothes redness and swelling. It promotes a calm, harmonious environment in the body at a cellular level.

3. Helps with Traumatic Injuries

Serrapeptase is widely used in Europe as a supplement for traumatic injury (such as sprains and torn ligaments), as well as the swelling associated with post-surgical patients.

4. Pain, Edema, and Swelling

Serrapeptase has been approved as a standard remedy in many European countries for swelling. A double-blind German study on the enzyme found that it could reduce swelling by up to 50% in post-operative patients. Patients taking serrapeptase experienced less pain than the control groups and, by the 10th day of the study, all patients taking the serrapeptase were completely pain-free.

5. Helps with Cystic Breast Disease

In a double-blind study, serrapeptase was found to reduce breast pain, breast swelling, and induration in 85.7% of the patients taking the supplement. This is related to the fact that the enzyme possesses fibrinolytic, proteolytic and anti-edemic properties.

6. Helps Infections in the Ear, Nose, and Throat

In one double-blind study, patients with acute or chronic ear, nose or throat diseases found significant symptom regression with serrapeptase. The enzyme can reduce the viscosity of mucous, thus facilitating drainage.

7. Helps with Carpal Tunnel Syndrome

Recent studies confirm the use of this enzyme for the reduction of symptoms associated with carpal tunnel syndrome.

8. Other Potential Benefits

Serrapeptase is used for a vast array of applications for human health and disease prevention. This includes therapeutic use for nerve damage, Multiple Sclerosis, chronic ear infections, hay fever, lung congestion, swollen glands, laryngitis, rhinitis, chronic pain, arthritis, back and neck pain, diabetes, ulcers, osteoporosis, prostate problems, rheumatoid arthritis, sports injuries (both prevention and recovery), post-operative scars and lesions, varicose veins, arterial diseases, angina, blood clots, anti-aging, restoration of healthy fibrin metabolism and reduction in C-Reactive Protein.

How to Read the Units of Measurement for Serrapeptase

Serrapeptase is measured in SUs (serrapeptase Units). This comes from the Japanese and Korean Pharmacopeias, whereby one unit of serrapeptase is the activity yielding a product equivalent of 1.0 ?g of Tyrosine per minute at pH 9.0 and 37 degrees Celsius on a casein substrate.

Where Can I Find The Best Source of Serrapeptase?

Veganzyme® contains a 100% vegan form of serrapeptase cultured from Serratia marcescens. It comes from all vegetarian, non-GMO sources, is kosher certified, gluten free, contains no animal product and is completely suitable for vegetarians and vegans. Veganzyme is the most advanced full-spectrum systemic and digestive enzyme formula in the world and is free from fillers and toxic compounds. This formula contains digestive enzymes which help digest fats (lipids), sugars, proteins, carbohydrates, gluten, fruits and vegetables, cereals, legumes, bran, nuts and seeds, soy, dairy and all other food sources. Veganzyme may also be used as a systemic enzyme blend to break down excess mucus, fibrin, various toxins, allergens, and excess clotting factors throughout your body.

References (4)
  1. Kee WH, Tan SL, Lee V, Salmon YM. The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trial. Singapore Med J. 1989 Feb;30(1):48-54.
  2. Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990 Sep-Oct;18(5):379-88.
  3. Kakinuma A, Moriya N, Kawahara K, Sugino H. Repression of fibrinolysis in scalded rats by administration of Serratia protease. Biochem Pharmacol. 1982 Sep 15;31(18):2861-6.
  4. Esch PM, Gerngross H, Fabian A. [Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase-- a prospective study]. Fortschr Med. 1989 Feb 10;107(4):67-8, 71-2. German.

†Results may vary. Information and statements made are for education purposes and are not intended to replace the advice of your doctor. Global Healing Center does not dispense medical advice, prescribe, or diagnose illness. The views and nutritional advice expressed by Global Healing Center are not intended to be a substitute for conventional medical service. If you have a severe medical condition or health concern, see your physician.

  • Krakondack

    It sounds promising, but it seems like it would have to be injected to have any effect. How would it otherwise survive the digestive enzymes, and pass into circulation? Until that’s clear, I don’t see how I can buy into this.

  • joe

    If that is the case, than how to justify the use of antibiotics , will the digestive enzymes not have the same effect that u had mentioned.

  • matt

    There are truly many benefits to serrapeptase, find them out at –

  • anneabell

    sounds to good to be true I just read that the product was recently recalled as they had no control studies i would love more informaiton on this

  • Vanessa

    I wanted to know If this would work on ednometriosis?

  • jen

    My sister has been trying
    to get me to take this for years. I finally agreed with her because I need to take Advil everyday for muscle stain from my job . I’ve been taking it for a week and have improvement in my pain. I haven’t taken any Advil since started it.

  • Cassie

    Vanessa, do you have endo? And if so, have you tried enzymes? I have an endometrioma cyst on my ovary and likely have endo. I just recently started proteolytic enzymes mainly to break down the cyst, but I just wanted to see if you were having any luck?


  • Happi

    It is an enzyme as are all the digestive secretions, if other prescribed pharmaceuticals can survive the digestive process I am sure that you will find that this product (as it is natural) will surely do the same thing quite with much less damage to the body as it is bioidentical

  • deepti

    Is it helpful in treating eye floaters?

  • I’ve seen some discussion on other forums about serrapeptase and eye floaters. I wouldn’t say it treats it but the limited information I saw sounded positive. Please let us know what you discover if you research it more!

  • Love

    Because it’s enteric coated google why pills come in that form

  • Loc

    The pills are enteric coated which protects it from the gastric juices it not being absorbed in the stomach but the small intestine which it’s absorbed from the blood stream

  • ahk

    Has any research been done on serrapeptase and autoimmune disease like celiac?

  • Haven’t seen anything, any other readers?

  • AIDS

    It gives you AIDS, be warned.

  • josh

    Has any research been done on serrapeptase and pulmonary fibrosis? Fast responses will be appreciated, thank you.

  • Do you have a paper due or something? My quick search on Pubmed didn’t yield anything but that may not cover all research that exists.

  • Narinder Singh

    Are their any harmful effects of daily use of serapeptidase .

  • Shouldn’t be, many people take it every day.

  • Pingback: The Health Benefits Of Serrapeptase | Healthy Sauce()

  • Cathi Oakes Tinney

    Hey pls tell me this will help yr round sinus mucus and chronic drainage. Pls.

  • We have heard people say it’s helped thin up their mucus. Hard to say absolutely until you try it.

  • Cathi Oakes Tinney

    great. any suggestions for year round chronic allergies? nothing helps.

  • Have you tried natural antihistamines?

  • Cathi Oakes Tinney

    no i havent. thanks and i will. i was not aware of these. will let you know how goes.

  • Reccia May Villanueva

    do you have distributor/store here in the Philippines?

  • maestra545

    Enteric capsules of serrapeptase are available from Source Naturals. I spoke to a customer representative and they assured me that they are forumlated for just that purpose.

  • Saiful Rimkeit

    I suppose this enzyme takes away clots because clots are composed of dead tissue, dead blood cells and other allied matter without affecting the rest of the blood structure and the enzyme becoming a blood thinner?
    If Dr Edward Group III DC, NP, DACBN, DCBCN, DABFM
    or someone qualified has the time, could this also be answered?

    Thank you.

    Geez, some of these posts are fairly old. Doc, you need a more effective way to expose these wondrous products and explanations to the World.

    Signed, oOne who seeks answers from NDs, osteopaths, herbalist MDs, DCs, etc.

  • Krista Burkling

    I am very interested in trying this. I am curious though. Is this safe for children & breastfeeding mothers? My 4 year old could really benefit from this & so could my husband & I. I am breastfeeding our 8 month old though.

  • You can always check with your doctor but nobody should have any trouble with enzymes. They’re just like little health power ups.

  • Pingback: Natural remedies for Endometriosis? |()

  • Colleen

    Currently I take tumeric 750mg am/pm for various aches and pains. It has helped, but wondering how the 2 might interact or if one is better on its own than the other? I have some arthritis, plantar fasciitis and treated surgically for uterine cancer.

  • Jenna Ice

    Its helped me with this ! like emmediate relief. also take capryllic acid with it

  • Jenna Ice

    it helps!

  • raelynnd

    does this help with blocked fallopian tubes?

  • patti walsh

    Hi, My doctor advised me to take Natural D-Hist by Ortho Molecular for allergies and it helped me with no side effects or drowsiness. Hope it helps!

  • Stephanie J Little Wolf

    Enteric coated works well on an empty stomach. This stuff is really powerfull. It causes herxing so use slowly at firzt and do lots ot detoxing. 10 days of being very tired……. but well worth it

  • Paul James Vecchio

    I’am 68 yrs old.I got A Fib from using a Device on my Feet ,like Thongs that you Plug into a Tens Unit. (New Device) (What follows is my opinion and backed up by real Facts) This Device sends a Electrical Surge up your legs every 10 seconds or so to Treat Nueropathy from Diabetes) (you can set the Rate ) Anyway,I used the Device for 4 months and Noticed How Tired I was. So I ended up in the Hospital with Angina,and at that time I was told that I had A Fib.I stopped using the Device 2 weeks earlier.So,I tried to tell the Doctors, (students at U.N.M.C. Omaha Ne.) University Hopital,that I got A Fib from this Device, (becuse I thought it Changed my Electrical System in My Heart) of couse they Laughed at me!So,I was put on Xeralto.2 months later,I Noticed my Hands and Fingers Falling asleep and being Numb.I also had Hemroids bad,( which I never had before),and Blood in my Stools.So I stopped taking Xeralto,and started Researching Alternative Meds.Thats how I Found Serrapeptase. After Taking 250000.00 (two hundred fifty thousand SU ‘s) on an Empty Stomach for 41/2 months, I called and said my A Fib was Gone!They Immediatley had me come in the Heart Center and said to me that I could not Stop taking Xeralto! She was a P.A. at the Heart Center of U.N.M.C. because my Heart Dr. was out of town at the time.She actually yelled at me ! I insisted that I was Taking Serrapeptase ,and she got mad and said,You can’t do that,I’ll put you on Cumidin or Warafin,and my Reply was,that those were Rat Poison,she then said,well,we will monitor you.I said,what am I a Lab Rat ? You’ll get a clot and Stroke out!I said I will Continue to Take Serrapeptase,Her Reply was,You Can Not Do That! Watch Me ,I said.So She arranged a Collar Heart Monitor that I wore for 5 Days. After 5 Days,I returned the Heart Monitor and they Removed it,and was told to call in 2 weeks later.I called in and they had no results at that Time. A week later I got a Call from the Heart Center,and was told that my Heart was in normal Sinic Rytham.I Know that They are Astonished ! No Further Contact from them! My A Fib is Gone! I still Take Serrapeptase Today!All this can be Verified! Paul James Vecchio Feb,2016.

  • Brian

    Are there any randomized placebo controlled studies available? In Japan, these stuff been pulled from market due to ineffectiveness according to Wikipedia. Anyone have an answer for that?

  • Pingback: Serrapeptase: The Miracle Enzyme That No One Seems To Know About | Collective-Evolution()

  • Pingback: Serrapeptase: The Miracle Enzyme That No One Seems To Know About | Best Natural News()

  • Pingback: A Magic Enzyme? – Real News Now()

  • Pingback: A Magic Enzyme? | Michigan Standard()

  • Pingback: A Magic Enzyme? | We Seek the Truth!()

  • Pingback: A Magic Enzyme? | We Seek the Truth!()

  • Pingback: The Healing Properties of Serrapeptase – Real News Now()

  • Pingback: The Healing Properties of Serrapeptase | Michigan Standard()

  • Pingback: The Healing Properties of Serrapeptase | We Seek the Truth!()

  • Pingback: The Healing Properties of Serrapeptase | We Seek the Truth!()

  • jdbaird

    It really does work, I’ve personally heard from people who had massive scarring from surgeries that serrapeptase caused the internal scarring to just go away. Also a friend of mine who had warts all over his hands and arms, took serrapeptase and the warts just flaked and fell off.

  • Jimmy Yost

    The serrapeptase I’m taking now has 120,000 serrapeptadase units per capsule. The instructions on the bottle say to take only one per day. I can tell it’s working but it’s going slow (for middle ear congestion). Can I take two capsules per day?

  • سعد يوسف البلداوي

    Some suppliers sell it with enteric coating. which will pass the stomach and dissolve after that. this makes it more effective.

  • سعد يوسف البلداوي

    Any tests of interaction with other supplements ? pills like Bee Pollen, royal jelly, Propolis, vitamin E & C, & Curcumen..would that require seperate timing or must drop some of these ?

  • Pingback: Arthritis – The Rust in Your Joints! | Soulfully Connecting()

  • barbbat

    I do (take two of the same dosage as you) and I’ve had no problems.

  • barbbat

    Not experienced any, but remember to take it with lots and lots of water so the capsule reaches your small intestine instead of being destroyed by stomach acid. I always try to stand up for about ten minutes (walk, clean, etc) until I feel the cap is out of my stomach. I take two 120,000 units per day on an empty stomach and have had no problems. My sinuses and ears have cleared up, but I’m really hoping for clean arteries!!

  • Pingback: The Health Benefits of Serrapeptase | The Health Coach()

  • tawnybill

    I have been on 1>2 – 120,00 capsules for about 6 months, increased for 10 >14 day stints to 3 caps a day first thing in the morning on an empty stomach to address a high cholesterol condition of many years. [BTW … I notice kidney irritation when I overdo it … so then I just take a week or 10 day break but diligently continue on.]

    Within a matter of 3-4 days of starting I noticed positive change and over the course of the last half year my blood now flows like ‘fine-red-wine’ as it should … [instead of like ketchup like it was in December 2015]

    The calcium build up between the inner and outer arterial walls in the femoral arteries serving the legs at the hip flex area had been the focus of several stents placed in December 2013 during my angioplasty to restore circulation.
    But the objective always was to open the artery to better flow, nothing to remove the calcium buildup was even considered or known possible by the North American trained medical team doing it.

    I would only find out about it’s effectiveness after I was told in my early December 2015 check-up that the stents at my hip area were now 100% PLUGGED with the arteries below them coated to about 50% restriction with build-up which my high cholesterol condition had caused, and I refused to have synthetic vein replacement done.

    Then the specialist basically folded up my chart and told me that ‘if he were me’ he wouldn’t gamble that within 6 months a “blood clot” would form or break lose and cause me a stroke, heart attack, or death. Concluding with “Without this surgery I really don’t expect to see you next yearly check up … Merry Christmas enjoy it and Good Luck”.

    I expect to keep on my regiment for at lest the next year … more if I need it.

  • Inge Roeder

    good for you. I started taking Serapeptases 120.000Su 4 days ago because I had a stroke July 22nd. 2016 were one blocked aterieon my brain on the MRI showed up. So I hope by taking Serapeptase to remove the clot.Also to help my Ad. Fip.

  • MPH

    Does Serrepeptase help remove scar tissue in lungs caused by NSIP?

  • LYNNE Shrubb

    A elderly client of mine began using this enzyme when she was diagnosed with angina and found it also helped to reduce her arthritis symptoms.

  • Sergio

    Brian, don’t trust Wikipedia with any articles regarding natural medicine. There seems to be an organized effort (by some people) to discredit every product or treatment that is not based on pharmacological products. The most common dismissal is “Not enough research”, even for products that have hundreds of papers from independent labs, but curiously none from any Big Pharma labs. Look somewhere else in the Internet for reliable information.

  • Christina

    I called today and spoke with this company, I’m confused b/c they said it’s still derived from the worm, which conflicts since the article says ‘vegetarian sources’? Are you meaning only that the bacteria is vegetarian once taken out of the silkworm? How do you otherwise get a vegan serrapeptase b/c I really truly want to use it but won’t take anything that could have killed silk worms. Tyia!

  • It’s derived from a bacterium typically found in silkworms but it’s not from silkworms. No silkworms were killed.

  • AvidReader

    Hello: I saw that no one has replied to “Josh” with his question about Pulmonary Fibrosis.
    My dad was diagnosed with Idiopathic Pulmonary Fibrosis about a year ago and the conventional docs only wanted him to try a couple of expensive experimental medications, of course. Neither of them appear to be helping whatsoever.
    Since this IPF causes honeycomb like scarring in the lungs, I was wondering if anyone has has any success with alleviating this IPF through the use of serrapeptase?
    I don’t think my dad has too much longer if we don’t find a viable solution to this lung scarring, so I’d appreciate any help/replies as soon as possible.
    Thank You!

  • AvidReader

    I was diagnosed with PAD and have a near
    total blockage in my left femur, causing intermittent pain when walking. Also identified were 2 additional, smaller
    blockages (one in femur and another in lower shin), both of which are thought to be causing low blood flow (40%) in the left leg.

    In addition, two days after an
    arteriogram to identify blocked vessels, my left foot went completely numb (from toes to mid-shin). The neurologist ordered
    several MRIs and did not find any sciatic nerve issues which would be causing the neuropathy. Neither the neurologist
    nor the vascular surgeon (who only recommends an arterial leg bypass) can state with any surety whether blocked arteries/low blood flow are the cause of the neuropathy.

    I read that Serrapeptase was assessed for use in dissolving
    plaque in the arteries while not harming arterial walls.

    Has anyone had success with Serrapeptase for this issue?

  • Michael (NW)

    Although serrapeptasecan be used to clean arteries, the concern I’ve read is that there is a possiblity that it could break up material which then could flow to the brain and cause a stroke. Is that possible? Are there ways to avoid this with how you take serrapeptase or…?

  • Gloria

    Hi is Serrapeptase can cure hyperthyroidism? And cyst?

  • Diane Dubuque

    Have you used this? I see it lists as having 500mg which seems like a lot. ty

  • Diane Dubuque

    Where are you buying this? ty

  • maestra545

    Stopped using it a while ago. Didn’t have much of an effect.

  • Bob Greenslade

    Have had both knees and hips replaced in the last11 months. Had right knee first last Feb. Swelling horrible and discolored tissue. Read this article before right hip. Got the enzyme on post op day 4…reduced swelling big time. Took every day for 10 weeks before left hip. Almost no swelling or bruising. Driving on post op day 4. Had left knee done 2 weeks ago…took 8 hours before surgery and when I got back to my room.. have taken mass amounts of enzyme daily…driving on post op day 6…walker 1 day. to cane by post op day 11. Friends could not believe reduction in swelling and how fast the scar is healing…will be curious what surgeon says on post op day 20 when I see him. This enzyme is awesome!

  • Pingback: A Single Supplement May Help With Swelling, Pain and Exercise Recovery | Serretia()

  • Koreiko House

    That is why you have to take serrapeptase on an empty stomach. Nice and easy 🙂

  • August Burk Secor

    Just an FYI…. This is not a Vegan product. It states on the ingredients that it contains lactose from milk, cheese or dairy. I am looking for a Serrapeptase that doesn’t contain any dairy, egg or bromelain. Id you know of anything the advise is appreciated.

  • kaia

    Google Veganzyme

  • Au

    Buy online dear

  • Sandra Etchell

    My ankles have been swollen ever since I took Cipro and they just won’t “go down”. I’ve seen blurbs about this online and that it is a side affect. I’m curious if this will help my situation.

  • AvidReader

    Anyone had success with Serrapeptase clearing blocked arteries in the legs?

  • AvidReader

    Hi Sandra:
    My feet & ankles are constantly swollen and won’t “go down” for a year and a half.
    After I took Dexamethasone for 10 days to relieve inflammation in my back while awaiting an MRI, about 2 days after finishing that medicine, my whole body swelled, within a day, and so much so by that evening I thought I was going to die. I had no idea why this happened. I’d never had a fluid issue. My landlord/friend said she thought my skin was going to burst and wanted me to go to the ER. I had so much fluid that I could feel and hear (literally) the water sloshing in my feet and legs.
    I spent the next 3 days and nights with my feet on piles of pillows (“feet over heart”) and my dad (a physician) started me on Lasix.
    I’m now on hydrochlorothiazide daily and have to wear the support stockings forever. I also am going to the wound clinic because the conventional docs have diagnosed swelling in legs is due to “poor circulation” and low blood flow and wounds on my leg don’t heal well or quickly because of all this.
    I also had an arteriogram last Feb 2016 and was diagnosed with Peripheral Arterial Disease; main left femur totally blocked and 2 other blockages.
    The doctors laugh at me when I told them this fluid problem started after I took that medicine, but truth is that I went online and read accounts from at least 5 other patients who had this same problem right after taking this same medicine.
    I am sure this medicine caused the fluid build-up and the blockages/low blood flow in my legs is keeping me from being able to get rid of it. The vascular doc and the doc at the wound care clinic run doppler tests every few months. They said that I have no problem with blood flow/circulation TO my feet, but little or no flow with the blood going back up, which is reason the fluid pools at ankles and feet.

    I often sleep for nearly a couple days at a time (Cancer fatigue & cancer meds) and when I do, with feet up, I actually wake up and have ankles!!! Unfortunately though, a couple hours sitting at the computer, and the fluid is back, my feet and ankles start swelling again and I have to go lie down with feet over heart for at least an hour. Otherwise, my ankles will look like elephant legs by the end of the day. Also unfortunately, putting my feet up means no blood flow to my feet, which then become very painful as they’re numb from peripheral neuropathy (which, by the way, also happened suddenly just after taking that medicine) and that pain is only relieved by dangling my feet over the bedside or getting up and walking around.
    I am going to try this serrapeptase, in hopes that it can clear the plaque buildup in my thigh arteries and restore blood flow.
    I wouldn’t doubt fora minute that your problem was caused by the cipro. I’d google “Cipro and Edema” and see what pops up.

  • Pingback: Remissioned MY Fibromyalgia | Gumption B'ma()

Get to know Dr. Group

These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.

All testimonials and product reviews are authentic from actual customers. Documentation is available for legal inspection. Product reviews are within range of typicality.

Information and statements made are for education purposes and are not intended to replace the advice of your treating doctor. Global Healing Center does not dispense medical advice, prescribe, or diagnose illness. The views and nutritional advice expressed by Global Healing Center are not intended to be a substitute for conventional medical service. If you have a severe medical condition or health concern, see your physician. This Web site contains links to Web sites operated by other parties. Such links are provided for your convenience and reference only. We are not responsible for the content or products of any linked site or any link contained in a linked site. Global Healing Center does not adopt any medical claims which may have been made in 3rd party references. Where Global Healing Center has control over the posting or other communications of such claims to the public, Global Healing Center will make its best effort to remove such claims.

© Copyright 1998 - 2017 | All Rights Reserved

Terms of Use | Privacy Policy