The Health Benefits of Cellulase

by Dr. Edward Group DC, NP, DACBN, DCBCN, DABFM Published on , Last Updated on


When we eat plants, we take in a large amount of plant cells surrounded by a fibrous complex called a cell wall. A major component of this cell wall is cellulose. Humans do not manufacture the cellulase enzyme needed to digest this type of fiber and must rely on fermentation by the flora in the large intestine.

This process allows us to break down a small portion of these plant fibers, but the rest act as bulking agents that are eliminated in the stool. Of course, some creatures are much more efficient than we are at this type of cellulose digestion: the cow, for example, has a ruminary stomach that is divided into four chambers and can hold massive amounts of cellulose-digesting microbes to break down the grass and hay that make up such a large part of its diet. This is why they can get big and strong from eating grass.

Similarly, if we eat lots of juicy, healthy greens, sprouts, and herbs, we want to make sure that we can digest them by having enough cellulase available. It would be a shame to waste the money we spend on fresh fruits and veggies.

Cellulase is produced naturally by different symbiotic fungi, protozoa, and bacteria that have the ability to catalyze cellulolysis (the breakdown of cellulose). In reality, there are different types of cellulases whose activity is pH-dependent: some are more active in an alkaline environment while others are more active in an acidic or neutral one.

Cellulase breaks down cellulose into beta-glucose. But what exactly is cellulose? It is a carbohydrate and a key part of the outer cellular structure of vascular plants. It could be considered one of the most abundant compounds in the world, as it is the basic building block for much of the plant kingdom, and is a primary food for much of the world’s living organisms.

The Health Benefits of Cellulase

I mentioned that cellulase turns cellulose into beta-glucose. This is important to understand when speaking about blood sugar in the human body. Glucose, or blood sugar, is the body’s key source of energy. It can be a problem, though, when we eat simple sugars that quickly elevate our blood sugar levels because the excess is converted into triglycerides and stored as body fat.

Glucose from cellulose is released slowly and should not dramatically increase blood sugar but rather provide a more stable fuel for the body. In addition, the fiber that is not digested by the cellulase can also slow down or decrease the absorption of fats including cholesterol.

How May Cellulase Enzymes Help?

  • Aiding in the hydrolysis of cellulose into energy-sustaining blood sugar that may help maintain optimal blood sugar levels
  • Helps keep cholesterol in the blood stream at optimal levels
  • Supporting cell membranes to keep them healthy from free radicals, toxic chemicals, and other entities that are harmful to cell membranes.
  • Aid in mediation of biofilm formation from cellulose produced by many types of pathogens.
  • Breaking down the polysaccharides of microbial biofilms.

In vitro studies show that the cellulase enzymes can stop the growth and increase the breakdown of biofilms produced by the bacteria Pseudomonas. This helps detoxify the intestinal tract, as well as the body’s major organ systems.

One study of nursing home patients taking a multi-enzyme formula containing cellulase found that they favorably increased markers of protein absorption. This indicates an improvement in digestion of a nutritional formula also given to the study participants, which would lead to an overall better nutritional status. Other tests also indicated an improvement in immune function for the patients. What is more, when the enzyme supplement was withdrawn, the positive benefits ended.

How to Read the Units of Measurement for Cellulase

Cellulase is measured in CUs, (Cellulase Unit). This FCC assay is based on the enzymatic hydrolysis of the interior β-1,4-Glucosidic bonds of a defined carboxymethyl cellulose substrate at pH 4.5 and 40°C, measured by a reduction in viscosity. The Federal Chemical Codex (FCC) is a division of USP (United States Pharmacopeia). It sets standards for ingredients. In the case of enzymes, FCC is a standard assay used to accurately determine the activity of enzymes. The current compendium is FCC VI.

Where Can I Find The Best Source of Cellulase?

The product VeganZyme® contains a 100% vegan form of Celluslase produced by the natural fermentation process of Trichoderma reesei and Bacillus licheniformis. It comes from all vegetarian, non-GMO sources, is kosher certified, gluten free, made in the USA, contains no animal product and is completely suitable for vegetarians and vegans.

VeganZyme is the most advanced full-spectrum systemic and digestive enzyme formula in the world and is free from fillers and toxic compounds. This formula contains digestive enzymes, which help digest fats (lipids), sugars, proteins, carbohydrates, gluten, fruits and vegetables, cereals, legumes, bran, nuts and seeds, soy, dairy, and all other food sources.

VeganZyme may also be used as a systemic enzyme blend to break down excess mucus, fibrin, various toxins, allergens, as well as excess clotting factors throughout your body.


  1. Loiselle M, Anderson KW. The use of cellulase in inhibiting biofilm formation from organisms commonly found on medical implants. Biofouling. 2003 Apr;19(2):77-85.
  2. Dale Kiefer. Promoting optimal nutrition with digestive enzymes. Life Extension Magazine. 2008 January.
  3. Glade MJ, Kendra D, Kaminski MV Jr. Improvement in protein utilization in nursing-home patients on tube feeding supplemented with an enzyme product derived from Aspergillus niger and bromelain. Nutrition. 2001 Apr;17(4):348-50.
  4. Iwasaki T, Hayashi K, Funatsu M. Purification and characterization of two types of cellulase from trichoderma koningi. J Biochem. 1965 Apr;57:467-77.Title
  5. G. Canevascini, D. Fracheboud, H. Meier. Fractionation and identification of cellulases and other extracellular enzymes produced by Sporotrichum (Chrysosporium) thermophile during growth on cellulose or cellobiose. Canadian Journal of Microbiology. 1983. 29(9): 1071-1080, 10.1139/m83-165.

†Results may vary. Information and statements made are for education purposes and are not intended to replace the advice of your doctor. Global Healing Center does not dispense medical advice, prescribe, or diagnose illness. The views and nutritional advice expressed by Global Healing Center are not intended to be a substitute for conventional medical service. If you have a severe medical condition or health concern, see your physician.

  • Thank you for the clear and concise info. Helpful šŸ™‚

  • Pingback: Angelwork Therapy | Systemic and Digestive Enzymes()

  • sher

    How well does this product work for weight loss?


  • karuna

    cellulose sucks

  • I understand that you’re selling the product, so you’ll probably choose favourable things to say, but I do have a few questions:

    1 – Your article states that “Glucose from cellulose is released slowly and should not dramatically increase blood sugar but rather provide a more stable fuel for the body.” Where is the reference for this? How would your gut know which glucose is from sugar and which from broken down cellulose?

    2 – How would the glucose released from the cellulose “help maintain optimal blood sugar levels”? Most people have too high blood sugar, not too low, so not sure how going from high to higher is optimal? Or is this product only recommended for people with chronic low blood sugar?

    3 – Where are the references that show any positive or neutral effect on blood sugar, blood fats, or cholesterol when taking a cellulase?

    4 – Since “the fiber that is not digested by the cellulase can also slow down or decrease the absorption of fats including cholesterol”, are you in fact saying that this is a benefit of eating fibre and NOT using the cellulase.

    5 – “One study of nursing home patients taking a multi-enzyme formula containing cellulase found that they favorably increased markers of protein absorption.” The product contained bromelain – a protease! The protease will help absorb the protein, what did the cellulase do? (See reference 3.)

Top Selling Supplements

Colon Cleanser Oxy-Powder® is the top quality colon cleanser. Promotes optimal colon health and regular bowel activity. Learn More

Liver Cleanse Kit This complete liver cleansing kit is a comprehensive approach to cleansing your liver. Learn More

Get to know Dr. Group

  Our Company




  • Global Healing Center
    2040 North Loop West, Ste. 234
    Houston, Texas 77018
    Telephone: 713-476-0016
    Toll Free: 1-800-476-0016
  • Contact Us