orotates

[Lindsay]

Is it necessary to take the calcium and magnesium orotates with protein - or anything else - for best absorption?

[ghchealth]

Calcium orotate is probably best taken after a meal or on an empty stomach. The primary reason for this is that it is alkaline and can potentially buffer the stomach acid. If this were to occur during a meal, it would decrease the digestion of the proteins that you were consuming. There are some formulations that provide an enteric coating in order to avoid this situation. Unfortunately, the enteric coating requires a number of glazes and chemicals that provide no benefit to your body. Ideally, calcium orotate should come with any potentially toxic excipients.